Kausik Chakraborty

Protein Folding and Stress Response



Kausik Chakraborty is interested in understanding the fundamental mechanism of protein folding homeostasis (Proteostasis) and its functional implication in misfolding stress. High throughput bacterial and yeast screening, and biophysical techniques are being used to study the role of chaperones in shaping protein sequence evolution and the role of different proteins and chaperones in signalling misfolding stress in the cell.

Advanced biophysical techniques like single molecule flourescence spectroscopy and fluorescence correlation spectroscopy will be used towards elucidating the molecular mechanism of stress sensing.

Selected Publications:

  • Chemical chaperones assist intracellular folding to buffer mutational variations. Bandyopadhyay A, Saxena K, Kasturia N, Dalal V, Bhatt N, Rajkumar A, Maity S, Sengupta S, Chakraborty K. Nat Chem Biol. 2012. 8(3):238-45.
  • Monitoring protein conformation along the pathway of chaperonin-assisted folding. Sharma S, Chakraborty K, Müller BK, Astola N, Tang YC, Lamb DC, Hayer-Hartl M, Hartl FU. Cell. 2008 Apr 4;133(1):142-53.
  • Essential role of the chaperonin folding compartment in vivo. Tang YC, Chang HC, Chakraborty K, Hartl FU, Hayer-Hartl M. EMBO J. 2008 May 21;27(10):1458-68.

Contact Information

Kausik Chakraborty
Office:
Room No. 104,
CSIR-IGIB,
Sukhdev Vihar,
Mathura Road,
New Delhi - 110 020
Tel: 91-11-29879 104
Fax: 91-11-27667 471
e-mail: kausik@igib.res.in

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