Munia Ganguli is involved in exploring the fundamental aspects of DNA delivery using cationic nanocarriers. Her major interests are:
Different intracellular and extracellular barriers in DNA delivery
Cell penetrating peptides in DNA delivery
Her laboratory has used Atomic Force Microscopy to identify different nanostructures formed during DNA condensation using cationic agents comprising polymers and peptides . DNA assembly has been shown to be controlled by the cationic agent which also affects intracellular DNA release and delivery efficiency.
- Highly efficient (R-x-R)-type carbamates as molecular transporters for cellular delivery. Patil KM, Naik RJ, Rajpal, Fernandes M, Ganguli M, Kumar VA., J Am Chem Soc. 2012. 134, 7196-7199.
- Structural rearrangements and chemical modifications in known cell penetrating peptide strongly enhance DNA delivery efficiency. Rajpal, Mann A, Khanduri R, Naik RJ, Ganguli M. 2012. J Control Release 157:260-71.
- Differences in DNA condensation and release by lysine and arginine homopeptides govern their DNA delivery efficiencies. Mann A, Thakur G, Shukla V, Singh AK, Khanduri R, Naik R, Jiang Y, Kalra N, Dwarakanath BS, Langel U, Ganguli M. 2011. Mol Pharm. 8:1729-41.
- Exogenous and cell surface glycosaminoglycans alter DNA delivery efficiency of arginine and lysine homopeptides in distinctly different ways. Naik RJ, Chandra P, Mann A, Ganguli M. J Biol Chem. 2011. 286(21):18982-93.
- DNA condensation by poly-L-lysine at the single molecule level: role of DNA concentration and polymer length. Mann, A., Richa, R., and Ganguli, M. J.Control Release. 2008. 125, 252-262.