Molecular pathobiology of respiratory diseases
U. Mabalirajan, Medico transformed into Researcher, is interested in exploring the molecular mechanisms of adaptive responses of airway epithelial cells against various exogenous and/or endogenous insults, for a fuller understanding of respiratory diseases. Using this understanding, he is in the process of developing etiology oriented rather than symptom oriented bedside therapeutics. Currently, he is trying to explore the mechanisms of airway epithelial injury and post-injury sequelae in asthma.
- Beneficial effects of high dose of L-Arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. Mabalirajan U, Ahmad T, Leishangthem GD, Joseph DA, Dinda AK, Agrawal A, and Ghosh B. J. Allergy. Clin. Immunol. (2010) 125:626-635.
- Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. Mabalirajan U, Aich J, Sharma SK and Ghosh B. J. Appl. Physiol. (2009) 107:1285-1292.
- Mepacrine attenuates the features of airway remodeling and reduces activity and expression of arginase in a mouse model of asthma Mabalirajan U, Aich J, Agrawal A, Ghosh B. Am. J. Physiol. Lung Cell Mol. Physiol. (2009) 297:L-411-419.
- Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model. Mabalirajan U, Dinda AK, Sharma SK and Ghosh B. J. Immunol. (2009) 183:2059-2067.
- Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. Mabalirajan U, Dinda AK, Kumar S, Roshan R, Gupta P, Sharma SK, and Ghosh B. J. Immunol. (2008) 181:3540-3548.