Rajesh S. Gokhale

Chemical & Systems Biology



Rajesh Gokhale is interested to elucidate mechanistic and spatiotemporal coherence of chemico-cellular processes underlying two distinct pathological diseases – Tuberculosis (TB) and Vitiligo.


The main focus of the group is to understand
  • Lipid Metabolic Networks in Mycobacteria and their implications in Extra-pulmonary TB.
  • Molecular regulatory networks that govern pigmentation homeostasis in skin.
  • Systems biology approach to decipher depigmenting disorder Vitiligo.

This group has discovered a new family of enzymes fatty acyl-AMP ligases that activate fatty acids as acyl adenylates. Further, they have demonstrated involvement of polyketide synthases in biosynthesis of complex Mycobacterium tuberculois lipids.

In skin biology program, a crucial role of IFNγ in downregulating melanogenesis process in melanocytes by controlling maturation of organelle melanosome has been delineated.

Selected Publications:

Contact Information

Rajesh S. Gokhale
Director

Room No. 106
CSIR-Institute of Genomics and Integrative Biology
Tel: +91 11 27662798, +91 11 27662407

Office:

Room No. 202
CSIR-IGIB, 
Sukhdev Vihar, 
Mathura Road, 
New Delhi - 110 025
Tel:91-11-29879202
rsg@igib.res.in
rsg@igib.in
Lab Webpage