Thiols: Biology and implications for human disease
Shantanu Sengupta’s primary focus is on the role of homocysteine and other thiol amino acids at the cellular level. He has adopted a combination of genetic, biochemical and proteomics approaches to study the consequences of abberant levels of this metabolite, implicated in cardiovascular disease and neurological diseases.
His research interests include:
Genetic basis of Cardiovascular Disease
Toxic effects of Thiol compounds like Homocysteine
Role of homocysteine in epigenetic modifications
He uses the power of yeast molecular genetics to understand the effects of metabolites in the thiol biosynthesis pathway.
- High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region. Sati, S., Tanwar, V.S., Anand Kumar, K., Patowary, A., Jain, V., Ghosh, S., Ahmad, S., Singh, M., Umakar Reddy, S., Chandak, G.R., Raghunath, M., Sivasubbu, S., Chakraborty, K., Scaria, V., Sengupta, S. 2012. Plos one. 7(2): e31621
- Proteomic Analysis of Zebrafish (Danio rerio) Embryos exposed to Cyclosporine A. Priyadarshini, R., Basak, T., Ahmad, S., Bhardwaj, G., Chauhan, R.K., Singh, R., Lalwani, M.K., Sivasubbu, S., Sengupta, S. 2012. J.Prot. 75: 1004-1017
- Converging evidence of mitochondrial dysfunction in a yeast model of homocysteine metabolism imbalance. Kumar, A., John, L., Maity, S., Manchanda, M., Sharma, A., Saini, N., Chakraborty, K., Sengupta, S. 2011. J. Biol. Chem. 286: 21779-95.
- Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. Kumar, J., Yumnam, S., Basu, T., Ghosh, A., Garg, G., Karthikeyan, G., Sengupta S. 2011. Clin Genet.79: 588-93.
- A single nucleotide polymorphism in transcobalamin II (I5V) induces structural changes in the protein as revealed by molecular modeling studies. Silla, Y., Chandamouli, B., Maiti, S., Sengupta, S. 2011. Biochemistry. 50:1396-402.