Research Areas

I.Genomics and Molecular Medicine

Genomics and Molecular Medicine is the major research focus of IGIB. From large collaborative projects like the Indian Genome Variation Consortium project to exploring genetics of complex disorders using a candidate gene approach several groups at IGIB are involved in studying the molecular basis of human diseases.

They focus on :

* Neuropsychiatric disorders like Schizophrenia
* Cardiovascular disease
* Diabetes and other complex disorders.

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II.Respiratory Disease Biology

A significant number of IGIB scientists focus on respiratory diseases using clinical, genetic, molecular and drug development approaches to tackle this challenging area.

The diseases of interest here are:

* Tuberculosis
* Asthma and Allergy
* Chronic Obstructive Pulmonary Disorder (COPD)

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III.Genome Informatics and Structural Biology

IGIB has over the years built up expertise in high-throughput data analysis and genome annotation. It is participating in international efforts like the Gen2Phen Consortium for unifying genetic variation databases. Genome Informatics also forms an integral part of most other research areas at IGIB and contributes to development of tools and hypotheses. The areas where informatics has contributed to genome analysis include:

* Indian Genome Variation: analysis of genome variation data
* Next-gen sequencing, assembly and annotation
* Unfolded proteins and adhesins
* Prediction of microRNA-target interaction
* Structural regulatory motifs in the genome

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IV.Energy and Environmental Biotechnology

Scientists at IGIB are exploring the rich microbial diversity of India and developing biotechnological applications using this resource to address issues pertaining to the environment and energy crisis. Different areas that are being pursued are:

* Microbial diversity and its exploration
* Hydrogen and bio-plastic from waste
* Waste water treatment using microbes

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V.Chemical & Systems Biology

Chemical approaches are essential in the understanding of many biological phenomena. Several research groups at IGIB have come together to utilize their varied expertise in different disciplines of chemistry and biology to address contemporary research problems that require interdisciplinary cross-talk. Research carried out at IGIB in this area involves:

* Chemical biology and systems biology of M. tuberculosis and skin pigmentation
* Chemically modified oligonucleotides for biological applications
* Nanobiotechnology
* Novel immunoassay procedures
* New molecules:

  • Linkers for biochip development
  • Peptide scaffolds and peptidomimetics
  • Quadruplex –stabilizing ligands

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