Rajesh Gokhale’s group is interested in understanding how metabolic networks are elaborately tuned in nature in three different model systems
Chemical Biology of Mycobacterium tuberculosis: His group is delineating metabolic pathways and mechanisms employed by Mycobacterium tuberculosis to generate molecular diversity that are crucial for its virulence and pathogenecity.
Dictyostelium discoideum Morphogenesis: Rajesh Gokhale’s group is investigating the role of polyketide synthases in understanding the complex differentiation process of Dictyostelium
Vitiligo: In this program, his group is investigating into the biochemical mechanisms underlying melanocyte-keratinocyte interactions in context of vitiligo.
- IFN-γ signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation. Natarajan VT, Ganju P, Singh A, Vijayan V, Kirty K, Yadav S, Puntambekar S, Bajaj S, Dani PP, Kar HK, Gadgil CJ, Natarajan K, Rani R, Gokhale RS.Proc Natl Acad Sci U S A. 2014 Feb 11; 83(17):111(6):2301-6
- Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. Arora P, Goyal A, Natarajan VT, Rajakumara E, Verma P, Gupta R, Yousuf M, Trivedi OA, Mohanty D, Tyagi A, Sankaranarayanan R, Gokhale RS. Nat Chem Biol. (2009) 5(3):166-73.
- Dissecting the functional role of polyketide synthases in Dictyostelium discoideum: biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol. Ghosh R, Chhabra A, Phatale PA, Samrat SK, Sharma J, Gosain A, Mohanty D, Saran S, Gokhale RS. J Biol Chem. (2008) 83(17):11348-54.
- A genetic locus required for iron acquisition in Mycobacterium tuberculosis. Krithika R, Marathe U, Saxena P, Ansari MZ, Mohanty D, Gokhale RS. Proc Natl Acad Sci U S A. (2006) 103(7):2069-74.
- Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. Trivedi OA, Arora P, Vats A, Ansari MZ, Tickoo R, Sridharan V, Mohanty D, Gokhale RS. Mol Cell. (2005) 17(5):631-43.
- Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria. Trivedi OA, Arora P, Sridharan V, Tickoo R, Mohanty D, Gokhale RS. Nature. (2004) 428(6981):441-5.