Translational Research in Lung Disease
Anurag Agrawal is interested in experimental and computational approaches for understanding biological and clinical aspects of respiratory diseases, especially asthma.
Current focus areas include
His lab has identified the critical role of mitochondrial dysfunction in the pathogenesis of asthma and discovered the mechanisms by which mesenchymal stem cells donate mitochondria to dysfunctional airway epithelium, attenuating experimental asthma.
His group has developed integrated solutions for healthcare delivery and digital data collection in resource-limited settings as well as computational tools for visualisation and analysis of complex medical datasets.
Symptoms and medical conditions in 204 912 patients visiting primary health-care practitioners in India: a 1-day point prevalence study (the POSEIDON study). Salvi S, Apte K, Madas S, Barne M, Chhowala S, Sethi T, Aggarwal K, Agrawal A, Gogtay J. Lancet Glob Health. 2015 Dec;3(12):e776-84.
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari BK, Jha KA, Barhanpurkar AP, Wani MR, Roy SS, Mabalirajan U, Ghosh B, Agrawal A. EMBO J. 2014 May 2;33(9):994-1010.
Integrating health care delivery and data collection in rural India using a rapidly deployable ehealth center. Agrawal A, Bhattacharya J, Baranwal N, Bhatla S, Dube S, Sardana V, Gaur DR, Balazova D, Brahmachari SK. PLoS Med. 2013;10(6):e1001468.
Exosome-enclosed microRNAs in exhaled breath hold potential for biomarker discovery in patients with pulmonary diseases. Sinha A, Yadav AK, Chakraborty S, Kabra SK, Lodha R, Kumar M, Kulshreshtha A, Sethi T, Pandey R, Malik G, Laddha S, Mukhopadhyay A, Dash D, Ghosh B, Agrawal A. J Allergy Clin Immunol. 2013 Jul;132(1):219-22.
Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation. Aich J, Mabalirajan U, Ahmad T, Agrawal A, Ghosh B. Nat Commun. 2012 Jun 6;3:877.