Archana Singh

Senior Scientist
Skin Biology

Archana Singh's lab is interested in understanding the architectural and cellular organization of human skin and employs guinea pig and transgenic mice models to understand the underlying molecular mechanisms that govern skin homeostasis during wound healing and pathological conditions including vitiligo.

Using high-resolution transmission electron microscopy, she is interested in

  • Molecular basis of perturbed keratinocyte biology in vitiligo
  • Epidermal-dermal cross-talk during cutaneous wound healing
  • Developing suitable animal models to understand factors regulating skin homeostasis

Vitiligo is primarily considered a disorder affecting the melanocytes, however, our recent study demonstrates widespread perturbations at architectural, cellular, and transcriptome levels suggesting presence of altered keratinocytes in vitiligo. Investigation of functional consequences of such alterations using in vivo wound healing studies revealed delayed healing kinetics in lesional skin further suggesting altered microenvironment in vitiligo skin.

Selected Publications:

Contact Information

Dr. Archana Singh
Office:
Room 223
CSIR-IGIB, 
Sukhdev Vihar, 
Mathura Road, 
New Delhi - 110 025
Tel: 91-11-29879223

e-mail:
archana@igib.in

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