Regulation of protein quality control in health and disease
Koyeli, a medico-turned researcher, is interested to elucidate the role of various regulators of protein quality control system and how it is perturbed in diseased conditions.
The current areas of research include:
- Molecular basis of substrate targeting to cognate chaperones
- Molecular mechanisms of Hsp70/Hsp110 molecular chaperones and the role of domain allostery in functionality of these molecular machines
- Elucidating the novel regulators of mitochondrial protein quality control
Koyeli’s recent work has elucidated the domain dynamics and heterogeneity of one of the master regulators of mitochondrial biogenesis, mitochondrial Hsp70, using single molecule FRET. Furthermore, using this elegant technique, she has elucidated the structural modulation of non-native proteins within the intra-cellular milieu.