Mitali Mukerji
Chief Scientist
Genomics and Molecular Medicine, Ayurgenomics
Mitali Mukerji research is in the broad area of understanding human genome structure and variation for its application in the discovery of biomarkers for predicting susceptibility to diseases, understanding human phenotypes and adaptations and mapping mutational histories. She has also developed the area of Ayurgenomics for application in precision medicine.
Her research interests include:
Multi-omic studies of healthy individuals stratified on the basis of Prakriti concepts of Ayurveda can enable identification of markers that can predict differential responsiveness to drugs and environment, susceptibility to diseases and provide actionable points for stratified interventions. Exonized Alu repeats in the transcriptome provides sites for miRNA interactions that can modulate transcript isoform density in stress further highlighting their involvement in novel regulatory networks.
Selected Publications:
- Alu-miRNA interactions modulate transcript isoform diversity in stress response and reveal signatures of positive selection. Pandey R, Bhattacharya A, Bhardwaj V, Jha V, Mandal AK, Mukerji M. Sci Rep. 2016 Sep 2;6:32348.
- Prasher B, Varma B, Kumar A, Khuntia BK, Pandey R, Narang A, Tiwari P, Kutum R, Guin D, Kukreti R, Dash D; TRISUTRA Ayurgenomics Consortium, Mukerji M. Ayurgenomics for stratified medicine: TRISUTRA consortium initiative across ethnically and geographically diverse Indian populations. J Ethnopharmacol. 2017 Feb 2;197:274-293.
- Aggarwal S, Gheware A, Agrawal A, Ghosh S, Prasher B, Mukerji M; Indian Genome Variation Consortium. Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach. J Transl Med. 2015 Jun 6;13:184.
- Mandal AK, Pandey R, Jha V, Mukerji M. Transcriptome-wide expansion of non-coding regulatory switches: evidence from co-occurrence of Alu exonization, antisense and editing. Nucleic Acids Res. 2013 Feb 1;41(4):2121-37.
- Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A; Indian Genome Variation Consortium, Prasher B, Mukerji M. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18961-6.
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