Neeru Saini

Principal Scientist
Apoptosis-based therapies for human diseases.

Dr Saini's research has provided new insights into miRNA-mediated regulation of apoptosis providing new opportunities for therapeutic interventions. During the last decade her laboratory has identified and characterized several miRNAs that hold immense potential as therapeutics. Currently she is understanding the regulation of cholesterol metabolism by microRNAs

She is interested in

  • Understanding role of microRNA(s) as regulator of mitochondrial activity/mitochondrial function
  • microRNA based therapeutics/diagnostics for cancer and psoriasis
  • Using Adipose derived stem cells (ADSC) for drug discovery and therapy

De novo lipogenesis, a hallmark for cancers is required for cellular transformation. Further it is believed that resistance to apoptosis and epithelial-to-mesenchymal-transition(EMT) facilitates metastasis via over-expression of anti-apoptotic Bcl-2. Her laboratory identified ACACA, FASN (the key enzymes of de novo fatty acid synthesis), HMGCR (the key enzyme of de novo cholesterol synthesis) and CYP27B1 as direct targets of hsa-miR-195. They further showed that ectopic expression of hsa-miR-195 in MCF-7 and MDA-MB-231 cells not only altered cellular cholesterol and triglyceride levels significantly but also resulted in reduced proliferation, invasion and migration. They also demonstrated that over expression of hsa-miR-195 decreased the Mesenchymal markers expression and enhanced Epithelial markers. In conclusion hsa-miR-195 potentially opens new avenues for the treatment of breast cancer

Selected Publications:

Contact Information

Neeru Saini
Office:
Lab 210
CSIR-IGIB,
Mall Road,
New Delhi - 110 007
Tel: 91-11-27666156/ Ext 136

e-mail:
nkhanna@igib.res.in
nsaini@igib.res.in