Rajender K. Motiani

Calcium Signaling and Integrative Disease Biology

Rajender Motiani, a veterinarian turned researcher, is interested in elucidating role of Calcium handling proteins in skin pigmentation and in studying Calcium channel regulation in cancer.

His prime research focus is to address following questions:

  • What is the role of dys-regulated calcium homeostasis in skin diseases like psoriasis and vitiligo?
  • How is the expression of Orai1 and Orai3 regulated in diseases like cancer and cardiovascular disorders?

Rajender identified a novel functional calcium channel protein, Orai3 in breast cancer and demonstrated that Orai3 is over-expressed in certain breast cancers. Further, using mouse model Orai3 was established as an oncogene. Current work is focused on elucidating regulation of Orai3 and Orai1 at transcriptional and translational level.

Selected Publications:

Contact Information

Rajender Motiani

Lab no. 218
Sukhdev Vihar, 
Mathura Road, 
New Delhi - 110 025


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