Calcium Signaling and Integrative Disease Biology
Rajender Motiani, a veterinarian turned researcher, is interested in elucidating role of Calcium handling proteins in skin pigmentation and in studying Calcium channel regulation in cancer.
His prime research focus is to address following questions:
- What is the role of dys-regulated calcium homeostasis in skin diseases like psoriasis and vitiligo?
- How is the expression of Orai1 and Orai3 regulated in diseases like cancer and cardiovascular disorders?
Rajender identified a novel functional calcium channel protein, Orai3 in breast cancer and demonstrated that Orai3 is over-expressed in certain breast cancers. Further, using mouse model Orai3 was established as an oncogene. Current work is focused on elucidating regulation of Orai3 and Orai1 at transcriptional and translational level.
- Emerging roles of Orai3 in pathophysiology. Motiani RK, Stolwijk JA, Newton RL, Zhang X, Trebak M. Channels (Austin). 2013;7(5):392-401.
- STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry. Shinde AV, Motiani RK, Zhang X, Abdullaev IF, Adam AP, González-Cobos JC, Zhang W, Matrougui K, Vincent PA, Trebak M. Sci Signal. 2013;6(267):ra18.
- miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat. Merlet E, Atassi F, Motiani RK, Mougenot N, Jacquet A, Nadaud S, Capiod T, Trebak M, Lompré AM, Marchand A. Cardiovasc Res. 2013;98(3):458-68.
- Orai3 is an estrogen receptor a-regulated Ca²? channel that promotes tumorigenesis. Motiani RK, Zhang X, Harmon KE, Keller RS, Matrougui K, Bennett JA, Trebak M. FASEB J. 2013;27(1):63-75.
- A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. Motiani RK, Abdullaev IF, Trebak M. J Biol Chem. 2010;285(25):19173-83.