Santosh Kumar Upadhyay

Biomolecular NMR Spectroscopy - Structural Biology


Santosh Kumar Upadhyay is an NMR structural biophysicist, interested NMR spectroscopy of protein-nucleic acid complexes.




The current areas of research include:
  • Interactions between protein and nucleic acid using solution Nuclear Magnetic Resonance (NMR).
  • Biophysical (ITC, CD, Fluorescence etc) and biochemical methods for studying binding, structural and conformational changes and dynamics of proteins and nucleic acids.

Selected Publications:

  • The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module. Dilworth D*, Upadhyay SK*, Bonnafous P, Edoo AB, Bourbigot S, Pesek-Jardim F, Gudavicius G, Serpa JJ, Petrotchenko, EV, Borchers CH, Nelson CJ, Mackereth CD. Nucleic Acids Research 2017 doi:https://doi.org/10.1093/nar/gkx852  *First Authors
  • 1H, 15N and 13C backbone and side chain resonance assignments of the RRM domain from human RBM24. Upadhyay SK*, Mackereth, CD. Biomol. NMR Assign. 2016, 10(2):237-40. doi: 10.1007/s12104-016-9674-y.[PubMed][Journal]
  • Binding and Thermodynamics of REV Peptide−ctDNA Interaction. Upadhyay SK*.  Biopolymers. 2017, 108(2). doi:10.1002/bip.22902 [PubMed] [Journal]
  • Structural insights into the inclusion complexes between clomiphene citrate and β-cyclodextrin: The mechanism of preferential isomeric selection. Maheshwari A, Saraswat H, Upadhyay SK*. Chirality. 2017 doi: 10.1002/chir.22712. [PubMed] [Journal][Cover Page Article]
  • Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner. Arya R, Dangi RS, Makwana PK, Kumar A, Upadhyay SK, Sundd M. Scientific Reports 2017, 7(1):1284. doi: 10.1038/s41598-017-01364-5. [PubMed] [Journal]
  • Structural insights into the acyl intermediates of the Plasmodium falciparum fatty acid synthesis pathway: the mechanism of expansion of the acyl carrier protein core. Upadhyay SK, Misra A, Srivastava R, Surolia N, Surolia A, Sundd M. J Biol Chem. 2009, 284(33):22390-400. doi: 10.1074/jbc.M109.014829. [PubMed] [Journal]
  • NMR and molecular modelling studies on the interaction of fluconazole with beta-cyclodextrin. Upadhyay SK*, Kumar G. Chem Cent J. 2009 Aug 10;3:9. doi: 10.1186/1752-153X-3-9. [PubMed] [Journal]

Contact Information

Santosh Kumar Upadhyay
Office:

CSIR-IGIB, 
Sukhdev Vihar, 
Mathura Road, 
New Delhi - 110 025
Tel: 91-11-29879157
e-mail:
skupadhyay@igib.in

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