Sheetal Gandotra

Scientist
Host pathogen interaction

We are interested in studying host-pathogen interaction with a focus on the cross-talk between the host and mycobacterial metabolism, especially lipid metabolism. Lipid droplets are central to lipid metabolism in cells, yet their ability to modulate innate immune responses is largely unexplored. We use a combination of cell biology, proteomics, and animal models to understand how these organelles orchestrate innate immune responses to intracellular pathogens. Understanding the dynamic role of these organelles will lead to development of host directed therapies in TB.
Her major interests are:

  • Macrophage triglyceride metabolism induced by M. tuberculosis is crucial for the innate immune response in TB

We identified a role for necrosis induced by virulent M. tuberculosis to be a major driver of macrophage triglyceride synthesis during TB infection. By modulating triglyceride levels in human macrophages, we identified a role for this lipid class in the innate immune response to infection. This work not only provides an explanation for the sequential amplification of inflammation during infection, it also provides a new avenue for developing host directed therapies to target inflammation in TB.

Selected Publications:

Contact Information

Sheetal Gandotra
Office:
Room No. 230,
CSIR-IGIB,
Sukhdev Vihar,
Mathura Road,
New Delhi - 110 020
Tel: 91-11-29879 230

Lab #219,
CSIR-IGIB,
Sukhdev Vihar,
Mathura Road,
New Delhi - 110 020
Tel: 91-11-29879 230

e-mail:
sheetal.gandotra@igib.in

Lab Webpage