Shantanu Sengupta

Thiols: Biology and implications for human disease



Shantanu Sengupta’s primary focus is on the role of homocysteine and other thiol amino acids at the cellular level. He has adopted a combination of genetic, biochemical and proteomics approaches to study the consequences of abberant levels of this metabolite, implicated in cardiovascular disease and neurological diseases.

His research interests include:
Genetic basis of Cardiovascular Disease
Toxic effects of Thiol compounds like Homocysteine
Role of homocysteine in epigenetic modifications

He uses the power of yeast molecular genetics to understand the effects of metabolites in the thiol biosynthesis pathway.

Selected Publications:

  • High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region. Sati, S., Tanwar, V.S., Anand Kumar, K., Patowary, A., Jain, V., Ghosh, S., Ahmad, S., Singh, M., Umakar Reddy, S., Chandak, G.R., Raghunath, M., Sivasubbu, S., Chakraborty, K., Scaria, V., Sengupta, S. 2012. Plos one. 7(2): e31621
  • Proteomic Analysis of Zebrafish (Danio rerio) Embryos exposed to Cyclosporine A. Priyadarshini, R., Basak, T., Ahmad, S., Bhardwaj, G., Chauhan, R.K., Singh, R., Lalwani, M.K., Sivasubbu, S., Sengupta, S. 2012. J.Prot. 75: 1004-1017
  • Converging evidence of mitochondrial dysfunction in a yeast model of homocysteine metabolism imbalance. Kumar, A., John, L., Maity, S., Manchanda, M., Sharma, A., Saini, N., Chakraborty, K., Sengupta, S. 2011. J. Biol. Chem. 286: 21779-95.
  • Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. Kumar, J., Yumnam, S., Basu, T., Ghosh, A., Garg, G., Karthikeyan, G., Sengupta S. 2011. Clin Genet.79: 588-93.
  • A single nucleotide polymorphism in transcobalamin II (I5V) induces structural changes in the protein as revealed by molecular modeling studies. Silla, Y., Chandamouli, B., Maiti, S., Sengupta, S. 2011. Biochemistry. 50:1396-402.

Contact Information:

Shantanu Sengupta
Office:
Room No. 201,
CSIR-IGIB,
Sukhdev Vihar,
Mathura Road,
New Delhi - 110 020
Tel: 91-11-29879 201
Fax: 91-11-27667 471
e-mail: shantanus@igib.res.in

Linkout

National Bioscience Award for Career Development 2011 (Biological Sciences)
Lab Website