Sivaprakash Ramalingam

Senior Scientist
Targeted genome editing and human disease modeling

Sivaprakash Ramalingam is interested studying the genetic determinants of monogenic hematological diseases. He is involved in identification of fetal hemoglobin associated genetic variants/modifiers for disease severity of sickle cell phenotype using genomic technologies. He is also interested in site-specific genetic correction and targeted addition of a DNA molecule in mammalian cells including patient-derived human induced pluripotent stem cells (hiPSCs) using gene-editing nucleases.

His major research interest includes:

  • Reprogramming of patient’s somatic cells into disease-specific iPSCs to understand the molecular mechanisms of underlying disease phenotypes.
  • Development of cellular genetic model by differentiating disease-specific hiPSCs into respective lineages and screening for lead compounds
  • Targeted genome editing of disease causing mutations in patient-derived hiPSCs

Selected Publications:

Contact Information

Office:

Room No. 330
CSIR-IGIB,
Sukhdev Vihar,
Mathura Road,
New Delhi - 110 025
Tel: 91-11-29879330
Email: sivaramalingam@igib.res.in

Lab Page

Linkout

Ramalingaswami fellowship, 2015, Department of Biotechnology