Souvik Maiti

Nucleic Acid Biophysics


Souvik Maiti is interested in unusual nucleic acid structures, their biological roles in non-coding RNA and targeting these entities by chemically engineered oligonucleotides or small molecules.

Using a combination of biophysical, biochemical and molecular biology methods coupled to computational predictions, we seek to:

  • Study RNA G quadruplexes and their influence on regulation of gene expression.
  • Identify small molecule modulators of miRNA function as potential therapeutic leads.

As part of our ongoing studies on the influence of RNA G quadruplexes on gene expression, we recently identified an unexpected augmentation of translation by a quadruplex motif in the 5' UTR of TGFB2.
As part of our efforts to develop small molecule leads for miRNA modulation, we demonstrated the potential re purposing of the well known aminoglycoside antibiotic, Streptomycin, to suppress levels of an oncogenic miRNA, miR-21.

Selected Publications:

Contact Information

Souvik Maiti
Office:
Room No. 108,
CSIR-IGIB,
Sukhdev Vihar,
Mathura Road,
New Delhi - 110 025
Tel: 91-11-29879108

e-mail:
souvik@igib.res.in

Lab Webpage