Research Areas

I.Genomics and Molecular Medicine

Genomics and Molecular Medicine is the major research focus of IGIB. From large collaborative projects like the Indian Genome Variation Consortium project to exploring genetics of complex disorders using a candidate gene approach several groups at IGIB are involved in studying the molecular basis of human diseases.

They focus on :

* Neuropsychiatric disorders like Schizophrenia
* Diabetes and other complex disorders.

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II.Cardio Respiratory Disease Biology

A significant number of IGIB scientists focus on respiratory diseases using clinical, genetic, molecular and drug development approaches to tackle this challenging area.

The diseases of interest here are:

* Tuberculosis
* Asthma and Allergy
* Chronic Obstructive Pulmonary Disorder (COPD)

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III. Chemical and Systems Biology

Chemical approaches are essential in the understanding of many biological phenomena. Several research groups at IGIB have come together to utilize their varied expertise in different disciplines of chemistry and biology to address contemporary research problems that require interdisciplinary cross-talk. Research carried out at IGIB in this area involves:

* Chemical biology and systems biology of M. tuberculosis and skin pigmentation
* Chemically modified oligonucleotides for biological applications
* Nanobiotechnology
* Novel immunoassay procedures
* New molecules:

  • Linkers for biochip development
  • Peptide scaffolds and peptidomimetics
  • Quadruplex –stabilizing ligands

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IV. Informatics and Big Data

IGIB has over the years built up expertise in high-throughput data analysis and genome annotation. It is participating in international efforts like the Gen2Phen Consortium for unifying genetic variation databases. Genome Informatics also forms an integral part of most other research areas at IGIB and contributes to development of tools and hypotheses. The areas where informatics has contributed to genome analysis include:

* Indian Genome Variation: analysis of genome variation data
* Next-gen sequencing, assembly and annotation
* Unfolded proteins and adhesins
* Prediction of microRNA-target interaction
* Structural regulatory motifs in the genome

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V. Integrative and Functional Biology