Genome Informatics and Structural Biology

IGIB has over the years built up expertise in high-throughput data analysis and genome annotation. It is participating in international efforts like the Gen2Phen Consortium for unifying genetic variation databases. Genome Informatics at IGIB also forms an integral part of most other research areas at IGIB and contributes to development of tools and hypotheses. Some of the areas where informatics has contributed to genome analysis includes:

* Indian Genome Variation: analysis of genome variation data
* Next-gen sequencing, assembly and annotation
* Unfolded proteins and adhesins
* Prediction of microRNA-target interaction
* Structural regulatory motifs in the genome

* Next-gen sequencing, assembly and annotation

The genome of a wildtype strain of zebrafish and the first Indian human genome have been sequenced at IGIB using Next-Gen sequencing. The data has been assembled and released for the public. A community effort to annotate the zebrafish genome using wiki tools has been spearheaded by IGIB scientists.

* Identification and functional characterization of unfolded proteins, adhesins

Hidden in the genome are proteins with unknown functions that refuse to give clues about their relevance through conventional comparative genomics that relies on conservation. A couple of groups at IGIB have used advanced computational analysis of the primary sequence of proteins to predict functions of proteins with unusual amino acid composition as well as proteins with unfolded domains, implying their involvement in microbial pathogenesis and transcriptional regulation respectively.